Cajun Chicken Alfredo Fettuccine

Featured in: Slow Cozy Dinners

This dish features tender chicken breasts seasoned with Cajun spices, pan-cooked to juicy perfection. The pasta is cooked al dente and enveloped in a creamy, smooth sauce made from Velveeta cheese, heavy cream, and Parmesan. A hint of cayenne adds optional heat, balanced by fresh parsley garnish. Perfect for a quick, comforting Southern-inspired meal with bold flavors.

Updated on Sun, 23 Nov 2025 12:14:00 GMT
Tender slices of Cajun Chicken Alfredo Fettuccine pasta in a creamy, cheese-covered bowl, ready to enjoy. Save to Pinterest
Tender slices of Cajun Chicken Alfredo Fettuccine pasta in a creamy, cheese-covered bowl, ready to enjoy. | savoringli.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This recipe quickly became a family favorite because of its bold flavors and creamy texture. I love how the Cajun seasoning adds just the right amount of heat without overpowering the Velveeta sauce.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional for extra heat) Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
The flavorful Cajun Chicken Alfredo Fettuccine showcases perfectly cooked pasta smothered in a rich Velveeta sauce. Save to Pinterest
The flavorful Cajun Chicken Alfredo Fettuccine showcases perfectly cooked pasta smothered in a rich Velveeta sauce. | savoringli.com

This dish always brings back memories of cozy family dinners where everyone requests seconds and the table buzzes with conversation.

Notes

Adjust Cajun seasoning for more or less heat Substitute rotisserie chicken for a quicker version Add sautéed bell peppers or mushrooms for extra flavor and color Pairs well with a crisp green salad and a chilled Chardonnay

Required Tools

Large pot Large skillet Knife and cutting board Tongs or pasta fork Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter) Contains wheat (fettuccine) Contains chicken Those with allergies should check ingredient labels for hidden allergens

A beautiful plate of Cajun Chicken Alfredo Fettuccine with parsley garnish, ready for a comforting, delicious meal. Save to Pinterest
A beautiful plate of Cajun Chicken Alfredo Fettuccine with parsley garnish, ready for a comforting, delicious meal. | savoringli.com

Enjoy your creamy spicy Cajun Chicken Alfredo with a fresh salad for a complete meal.

Recipe Questions & Answers

How do I achieve a creamy sauce without clumping?

Simmer the cream gently and stir Velveeta cheese in gradually until melted smoothly. Adding reserved pasta water helps loosen consistency.

Can I use another pasta instead of fettuccine?

Yes, wide noodles like linguine or tagliatelle work well, as they hold the creamy sauce nicely.

How spicy is the Cajun seasoning in this dish?

It provides a moderate heat that can be adjusted by adding or omitting cayenne pepper based on preference.

What alternative cheeses can replace Velveeta?

For a similar creaminess, try processed cheeses or a blend of mild cheddar and cream cheese, melted carefully.

How should the chicken be cooked for best texture?

Cook chicken breasts over medium-high heat until golden and fully cooked, then let rest before slicing to retain juiciness.

How can I add more vegetables to this dish?

Sauté bell peppers, mushrooms, or spinach separately and toss them into the sauce before combining with pasta.

Cajun Chicken Alfredo Fettuccine

Spicy Cajun-seasoned chicken served over fettuccine with a smooth Velveeta cheese sauce and Parmesan.

Prep Time
15 minutes
Time to Cook
25 minutes
Overall Time
40 minutes
Created by savoringli Lila Anderson


Skill Level Easy

Cuisine Type American (Cajun-inspired)

Makes 4 Serving Size

Diet Details None specified

Ingredient List

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 ounces Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon ground black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Step-by-Step Instructions

Step 01

Cook Pasta: Bring a large pot of salted water to a boil. Cook fettuccine according to package directions until al dente. Drain, reserving ½ cup pasta water; set aside.

Step 02

Prepare Chicken: Pat chicken breasts dry and evenly coat both sides with Cajun seasoning.

Step 03

Cook Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden and internal temperature reaches 165°F (74°C). Remove and rest 5 minutes, then slice thinly.

Step 04

Sauté Garlic: Reduce skillet heat to medium. Add butter and minced garlic; sauté for 1 minute until fragrant.

Step 05

Prepare Sauce: Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring frequently until melted and smooth.

Step 06

Finish Sauce: Mix in grated Parmesan, black pepper, and cayenne pepper if desired. Adjust salt to taste. If sauce is too thick, gradually add reserved pasta water until desired consistency is reached.

Step 07

Combine Pasta and Sauce: Toss cooked fettuccine in sauce until fully coated.

Step 08

Plate and Garnish: Divide pasta onto plates, top with sliced Cajun chicken, then garnish with chopped parsley and extra Parmesan if desired.

Equipment Needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Info

Review every ingredient for allergens. If unsure, check with a healthcare provider.
  • Contains milk/dairy products (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine pasta)
  • Contains poultry (chicken)

Nutrition Info (per portion)

Serves for general info – not a replacement for professional advice.
  • Calorie Count: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g